The Computational Physics Group at Georgia Tech is doing state-of-the-art research on computational modeling, numerics, and HPC for biomedical and defense applications. Our methods are often buttressed by the latest machine learning algorithms, utilize novel hardware architectures (quantum, RISC-V), and scale to the world’s largest supercomputers. At present, we are particularly interested in applying our methods to the design of hypersonic vehicles and biomicrofluidic devices for detecting and treating disease and creating vaccines.